What are the Long-Term Side-Effects of Antidepressants?

What are the Long-Term Side-Effects of Antidepressants?

Understanding the Long-term Side Effects of Antidepressants

If you’ve been recently diagnosed with depression and are weighing the pros and cons of taking antidepressant medication, or if you’ve been on antidepressants for some time and are starting to feel the effects – you’re probably wondering if antidepressants have any long-term side effects.

While antidepressant medications serve an important purpose for many people, their assistance does come at a price – these being side effects of the medication.

Let’s explore the long-term side effects of taking antidepressants.

Weight Gain

Taking antidepressant medications long term may result in weight gain, according to a 10-year study published in a 2018 BMJ journal.

The study found that people who began antidepressants at a normal body mass were more likely to become overweight and people who started as overweight were likely to transition to obese.

In fact, people on antidepressants were 21 percent more likely to gain 5 percent or more of their body weight over ten years. If you’re wondering where you stand, your risk may be the greatest in the second or third years of taking antidepressant medication.


Many studies have been done on the link between type 2 diabetes and antidepressants. And the results show a clear connection. A systematic review published in the American Diabetes Association’s journal, Diabetes Care found that there are many factors at play, but there’s enough evidence to suggest that diabetes is a side effect of antidepressant medications.

Researchers looked at 22 studies and three systemic reviews to evaluate antidepressant’s role in diabetes. They found that variables, such as the type of antidepressant medication, dosage, and duration, impacted the results. But still, there was a modest connection between the two.


While we wait for the medical community to conduct more research, we should be aware of the connection. If you’re on antidepressants, talk to your doctor about how you can keep your risk for type 2 diabetes down.


If you’ve been on antidepressants for some time, there’s a good chance you’re starting to think about weaning off of them. But the problem with that lies in how antidepressants work. Regardless of type, antidepressants interfere with your brain’s ability to regulate serotonin and norepinephrine.

Whenever you stop, or sometimes when you make a drastic cutback, the brain goes into overdrive to regulate these two neurotransmitters. This can lead to new bouts of depression.

For this reason, antidepressants alone are not a long-term solution. They can certainly be helpful if you’re having serious thoughts of self-harm or if your depression is interfering with your life. But the ultimate goal should be to heal the issues that are at the root of your depressive symptoms.

Post-SSRI Sexual Dysfunction (PSSD)

Selective Serotonin Reuptake Inhibitors (SSRIs) are currently the most commonly prescribed medications to treat depression, but we’re learning about a new side effect that may have a lasting impact.

Post-SSRI Sexual Dysfunction (PSSD) is a term that describes a series of sexual side effects that are associated with taking SSRI antidepressants. Unfortunately for many, these symptoms may persist even after they stop taking the drugs.

Symptoms of PSSD include erectile dysfunction, vaginal dryness, poor orgasms, low sex drive and a loss of sensation in the genitals. A study published in Sexual Medicine Reviews notes that some patients see symptoms shortly after taking their first dose while others begin having symptoms over days or weeks.

There is no treatment for PSSD at the moment. If you’re experiencing any of these symptoms, talk to your doctor about switching medications or weaning off treatment.

It’s important to note that mental health disorders can have sexual side effects, so it can be difficult for doctors to pinpoint the root cause of sexual dysfunction. Still, if these symptoms occur shortly after starting SSRIs, your medication is the likely culprit.


Addiction to antidepressants is extremely rare, but it is possible. It’s also possible to overdose on antidepressants, whether you take high doses on purpose or by accident. If you have a history of substance abuse, talk to your doctor about whether antidepressant medications are right for you.

Other Reported Side Effects of Antidepressants

A 2016 Patient Preference and Adherence article published results of a questionnaire on the long-term side effects of antidepressants. Overall, patients reported being less depressed and had a better quality of life. About 30 percent of people reported having severe depression.

Below are some of the common symptoms noted in the report.

  • Emotional numbness (65 percent)
  • Not feeling like themselves (54 percent)
  • Reduced positivity (46 percent)
  • Addictive thoughts and feelings (43 percent)
  • Caring less about other people (36 percent)
  • Suicidal feelings (36 percent)

Weighing the Pros and Cons of Antidepressants

If you’re dealing with mild to moderate depression, take a close look at the long-term side effects of a medication before you start on a plan.

Once you start taking medications like SSRIs, your body will become accustomed to them, and it may be difficult to get off the medication without experiencing side effects.

If you’re suffering from moderate to major depression, talk to your doctor about the pros and cons of medication. In some cases, it may be your best option, but you should have all the facts before you decide.

Trevor McDonaldTrevor McDonald

Trevor is a freelance writer and recovering addict and alcoholic who has been clean and sober for over 5 years. He graduated from Penn State University with a B.A. in Liberal Arts. Since his recovery began he has enjoyed using his talent for words to help spread treatment resources and addiction awareness. In his free time, you can find him working with recovering addicts or outside enjoying about any type of fitness activity imaginable.

Jul 10, 2018
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